PTCL Disease Overview

PTCL is typically an aggressive, difficult to diagnose non-Hodgkin
lymphoma largely associated with a poor prognosis2-4

Incidence of PTCL has increased and accounts for ~10% of
non-Hodgkin lymphomas4,5

Peripheral T-cell lymphoma incidence rates by subtype

aIncludes all subtypes in chart and 3 subtypes not listed due to low incidence: hepatosplenic gamma/delta T-cell lymphoma, enteropathy-type intestinal T-cell lymphoma, and subcutaneous panniculitis-like T-cell lymphoma.

  • Improved recognition of previously underdiagnosed lymphoma subtypes and growth in an aging population may account for increased incidence of the disease4,6
NEXT: TYPES OF PTCL

Important Safety Information

WARNINGS AND PRECAUTIONS

ADVERSE REACTIONS

Peripheral T-Cell Lymphoma

The most common Grade 3/4 adverse reactions (>5%) regardless of causality in Study 3 (N=131) were thrombocytopenia (24%), neutropenia (20%), anemia (11%), asthenia/fatigue (8%), and leukopenia (6%), and in Study 4 (N=47) were neutropenia (47%), leukopenia (45%), thrombocytopenia (36%), anemia (28%), asthenia/fatigue (19%), pyrexia (17%), vomiting (9%), and nausea (6%).

Infections were the most common type of serious adverse event reported in Study 3 (N=131) and Study 4 (N=47). In Study 3, 26 patients (20%) experienced a serious infection, including 6 patients (5%) with serious treatment-related infections. In Study 4, 11 patients (23%) experienced a serious infection, including 8 patients (17%) with serious treatment-related infections.

The most common adverse reactions regardless of causality in Study 3 (N=131) were nausea (59%), asthenia/fatigue (55%), thrombocytopenia (41%), vomiting (39%), diarrhea (36%), and pyrexia (35%), and in Study 4 (N=47) were asthenia/fatigue (77%), nausea (75%), thrombocytopenia (72%), neutropenia (66%), anemia (62%), leukopenia (55%), pyrexia (47%), anorexia (45%), vomiting (40%), constipation (40%), and diarrhea (36%).

DRUG INTERACTIONS

USE IN SPECIFIC POPULATIONS

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