Differential Diagnosis
of Common PTCL Subtypes

75% of patients diagnosed with PTCL are comprised of 3 subtypes3

aPTCL diagnoses in North America (N=332). The other 25% of diagnosed PTCL subtypes include natural killer T-cell lymphoma, adult T-cell leukemia/lymphoma, enteropathy-type, hepatosplenic, primary cutaneous ALCL, subcutaneous panniculitis-like, and unclassifiable.3

AITL=angioimmunoblastic T-cell lymphoma; ALCL=anaplastic large cell lymphoma; PTCL-NOS=peripheral T-cell lymphoma, not otherwise specified.

The majority of patients with PTCL have either
stage III or IV disease at the time of diagnosis.3

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Important Safety Information

WARNINGS AND PRECAUTIONS

ADVERSE REACTIONS

Peripheral T-Cell Lymphoma

The most common Grade 3/4 adverse reactions (>5%) regardless of causality in Study 3 (N=131) were thrombocytopenia (24%), neutropenia (20%), anemia (11%), asthenia/fatigue (8%), and leukopenia (6%), and in Study 4 (N=47) were neutropenia (47%), leukopenia (45%), thrombocytopenia (36%), anemia (28%), asthenia/fatigue (19%), pyrexia (17%), vomiting (9%), and nausea (6%).

Infections were the most common type of serious adverse event reported in Study 3 (N=131) and Study 4 (N=47). In Study 3, 26 patients (20%) experienced a serious infection, including 6 patients (5%) with serious treatment-related infections. In Study 4, 11 patients (23%) experienced a serious infection, including 8 patients (17%) with serious treatment-related infections.

The most common adverse reactions regardless of causality in Study 3 (N=131) were nausea (59%), asthenia/fatigue (55%), thrombocytopenia (41%), vomiting (39%), diarrhea (36%), and pyrexia (35%), and in Study 4 (N=47) were asthenia/fatigue (77%), nausea (75%), thrombocytopenia (72%), neutropenia (66%), anemia (62%), leukopenia (55%), pyrexia (47%), anorexia (45%), vomiting (40%), constipation (40%), and diarrhea (36%).

DRUG INTERACTIONS

USE IN SPECIFIC POPULATIONS

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